反应详情

Chloro methylformate (0.24 g, 0.0026 mol) dissolved in CH2Cl2 (5 ml) was added dropwise to a stirred solution of 5,6-methylenedioxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (0.80 g, 0.0022 mol) and triethylamine in CH2Cl2 (10 ml). The mixture was then stirred at room temperature for 19 h. The CH2Cl2 -solution was washed with water, dried (MgSO4) and the solvent was evaporated giving the desired product as an oil (0.06 g, 6%). NMR data for the final product is given below.

1. washThe CH2Cl2 -solution was washed with water
2. dry with materialdried (MgSO4)
3. customthe solvent was evaporated