反应详情

Phenylisocyanate (0.20 g, 0.00167 mol) dissolved in CH2Cl2 (5 ml) was added dropwise under stirring to a solution of 5,6-methylenedioxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole (0.50 g, 0.00139 mol) and triethylamine (0.28 g, 0.00278 mol) in CH2CL2 (15 ml). The mixture was then stirred at room temperature for 50 hours. The CH2Cl2 -solution was washed with water, dried (MgSO4) and the solvent was evaporated giving the desired product as an oil (0.03 g, 5%). NMR data for the final product is given below.

1. additionwas added dropwise
2. washThe CH2Cl2 -solution was washed with water
3. dry with materialdried (MgSO4)
4. customthe solvent was evaporated