3-Aminobenzoic Acid → HCID 54052026, compound

HRID 2248494Notes

Reaction equation

HRID 2248494 reaction equation
C(OC(=O)CCN[C:13](=[O:41])[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([NH:20][C:21](=[O:40])[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][NH:29][C:30]([O:32][CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[O:31])[CH:15]=1)C1C=CC=CC=1.NC1C=C(C=CC=1)C(O)=[O:48]>>[CH2:33]([O:32][C:30]([NH:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][C:21]([NH:20][C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[C:13]([OH:41])=[O:48])=[O:40])=[O:31])[C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1

Participants

3

Reactant 2

HCID 74193-Aminobenzoic AcidHCID 19996351HCID 19996351, compound

Product 1

HCID 54052026HCID 54052026, compound

Procedure

The ester starting material (m.p. 123°-124° C.) is obtained by coupling 8-[1-(benzyloxy)formamidooctanoic acid and 3-aminobenzoic acid to give m-[8-[1-(benzyloxy)formamido]octanamido]benzoic acid, m.p. 167°-168° C., and reacting the latter with β-alanine benzyl ester p-toluenesulphonate.

Sources & evidence

ORD record
ord-28660bc697ed443084911cc205a4f599
Source dataset
uspto-grants-1991_08
Patent number
US05039805

Reaction notes

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