HCID 19996463, compound → HCID 19996380, compound

HRID 2248495Notes

Reaction equation

HRID 2248495 reaction equation
C([O:5][C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([NH:16][C:17]1[CH:18]=[C:19]([CH:28]=[C:29]([N+:31]([O-:33])=[O:32])[CH:30]=1)[C:20]([NH:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[O:21])=[O:15])=[O:7])(C)(C)C>C(O)=O>[CH:6]([OH:7])=[O:5].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][C:14]([NH:16][C:17]1[CH:18]=[C:19]([CH:28]=[C:29]([N+:31]([O-:33])=[O:32])[CH:30]=1)[C:20]([NH:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])=[O:21])=[O:15]

Participants

3

Reactant 1

HCID 19996463HCID 19996463, compound

Product 1

HCID 19996380HCID 19996380, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

807 mg of N-[3-[6-(1-t-butoxyformamido)hexanamido]-5-nitrobenzoyl]-β-alanine are left to stand at room temperature in 2.7 ml of formic acid for 18 hours. The solvent is evaporated in a vacuum. The residue is dissolved in water and the solution is evaporated in a vacuum. There are obtained 573 mg of N-[3-(6-aminohexanamido)-5-nitrobenzoyl]-β-alanine formate (2:1), MS: 367 (67, M+H).

Workup

  1. customThe solvent is evaporated in a vacuum
  2. dissolutionThe residue is dissolved in water
  3. customthe solution is evaporated in a vacuum

Sources & evidence

ORD record
ord-ba8977db62044839843ecbc8d6c5daf2
Source dataset
uspto-grants-1991_08
Patent number
US05039805

Reaction notes

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