3-Aminobenzoic Acid → HCID 86744991, compound

HRID 2248500Notes

Reaction equation

HRID 2248500 reaction equation
C(OC(=O)CCNC(=O)[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([NH:20][C:21](=[O:36])[CH2:22][CH2:23][CH2:24][NH:25][C:26]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:27])[CH:15]=1)C1C=CC=CC=1.C([O:46][C:47](NCCCC(O)=O)=[O:48])C1C=CC=CC=1.NC1C=C(C=CC=1)C(O)=O>C(O)C>[CH2:29]([O:28][C:26]([NH:25][CH2:24][CH2:23][CH2:22][C:21]([NH:20][C:16]1[CH:15]=[CH:14][CH:19]=[CH:18][C:17]=1[C:47]([OH:48])=[O:46])=[O:36])=[O:27])[C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

Participants

5

Reactant 3

HCID 74193-Aminobenzoic AcidHCID 211844-(((Benzyloxy)carbonyl)amino)butanoic acidHCID 19996426HCID 19996426, compound

Product 1

HCID 86744991HCID 86744991, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

For the preparation of the ester starting material, m.p. 119°-120° C. (from ethanol), 4-[1-(benzyloxy)formamido]butyric acid is reacted with m-aminobenzoic acid to give m-[4-[1-(benzyloxy)formamido]butyramidobenzoic acid and the latter is reacted with β-alanine benzyl ester.

Sources & evidence

ORD record
ord-62ff63dfe4dc49189760b7786129df49
Source dataset
uspto-grants-1991_08
Patent number
US05039805

Reaction notes

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