Ammonium Acetate → HCID 67828147, compound

HRID 2248519Notes

Reaction equation

HRID 2248519 reaction equation
[IH:1].[CH3:2][O:3][C:4](=[O:36])[C@H:5]([CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[NH:6][C:7](=[O:27])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH:14][C:15](=[O:26])[C:16]2[CH:21]=[CH:20][C:19]([C:22](SC)=[NH:23])=[CH:18][CH:17]=2)[CH:9]=1.C([O-])(=O)C.[NH4+:41].CCOCC.C(OC(C)C)(C)C>CO>[IH:1].[CH3:2][O:3][C:4](=[O:36])[C@H:5]([CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[NH:6][C:7](=[O:27])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([NH:14][C:15](=[O:26])[C:16]2[CH:21]=[CH:20][C:19]([C:22](=[NH:41])[NH2:23])=[CH:18][CH:17]=2)[CH:9]=1

Participants

5

Reactant 3

HCID 517165Ammonium AcetateHCID 21919906Ether isopropyl etherHCID 67945798HCID 67945798, compound

Product 1

HCID 67828147HCID 67828147, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 3-(t-butoxycarbonyl)-N-[m-[p-[1-(methylthio)formimidoyl]benzamido]benzoyl]-L-alanine methyl ester hydroiodide in methanol is reacted with ammonium acetate in an analogous manner to that described in Example 33 B) h). There is obtained in 71% yield N-[m-(p-amidinobenzamido)benzoyl]-3-(t-butoxycarbonyl)-L-alanine methyl ester hydroiodide in the form of a colourless solid, m.p. 118°-120° C. (ether/isopropyl ether), MS: 469 (M+1)+.

Sources & evidence

ORD record
ord-4833333a903046ffafc884a15ff39f4d
Source dataset
uspto-grants-1991_08
Patent number
US05039805

Reaction notes

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