Sodium Acetate → HCID 10405634, compound

HRID 2248572Notes

Reaction equation

HRID 2248572 reaction equation
[N:1]1([C:9]2[CH:14]=[CH:13][C:12]([S:15]([NH:18][CH2:19][CH2:20][CH2:21][CH2:22][C:23]([OH:25])=O)(=[O:17])=[O:16])=[CH:11][CH:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[N:1]1([C:9]2[CH:14]=[CH:13][C:12]([S:15]([N:18]3[CH2:19][CH2:20][CH2:21][CH2:22][C:23]3=[O:25])(=[O:17])=[O:16])=[CH:11][CH:10]=2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 19994505HCID 19994505, compound

Product 1

HCID 10405634HCID 10405634, compoundYield 88.8%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

3.4 g of product obtained in stage A are heated to reflux for 1 hour with 3.4 g of sodium acetate in 68 cm3 of acetic anhydride. The mixture is cooled to room temperature and evaporated to dryness, the residue is taken up in 50 cm3 of water, filtered off and dried and 2.87 g of expected product are obtained. M.p. 150°-152° C. After crystallization in isopropanol, 1.9 g of pure product are obtained. M.p. 152°-153° C.

Workup

  1. customevaporated to dryness
  2. filtrationfiltered off
  3. customdried

Sources & evidence

ORD record
ord-688ea500559343b7b201a170e90bdf68
Source dataset
uspto-grants-1991_08
Patent number
US05041436

Reaction notes

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