Ammonium Chloride → N-[(diphenylmethyl)]-1H-1,2,4-triazol-1-amine

HRID 2248611Notes

Reaction equation

HRID 2248611 reaction equation
[N:1]1([N:6]=[C:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]=[N:4][CH:3]=[N:2]1.[BH4-].[Na+].[Cl-].[NH4+]>C(O)C.C(OCC)(=O)C>[C:14]1([CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[NH:6][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

6

Reactant 3

HCID 25517Ammonium ChlorideHCID 4311764Sodium borohydrideHCID 19994944HCID 19994944, compound

Product 1

HCID 19994960N-[(diphenylmethyl)]-1H-1,2,4-triazol-1-amine

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Added to a solution of 2.0 g (8.1 mmol) of N-(1H-1,2,4-triazol-1-yl)-benzophenoneimine in 20 mL of ethanol was 0.45 g (12.1 mmol) sodium borohydride at room temperature. After stirring 41/2 h, aqueous ammonium chloride was added and the mixture was diluted with ethyl acetate, washed with water and brine, dried (MgSO4) and concentrated. Product can be purified by crystallization from n-butylchloride; yield 1.7 g (84%); mp 142°-145° C.

Workup

  1. customat room temperature
  2. additionwas added
  3. washwashed with water and brine
  4. dry with materialdried (MgSO4)
  5. concentrationconcentrated
  6. customProduct can be purified by crystallization from n-butylchloride

Sources & evidence

ORD record
ord-31b1038786e34c9f9edd34282796045d
Source dataset
uspto-grants-1991_08
Patent number
US05041458

Reaction notes

Loading…