Methyl 3,3-bis(methoxycarbonyl methylthio)-2-methyl-propionate → Methyl 3-hydroxy-4-methylthiophene-2-carboxylate

HRID 2248742Notes

Reaction equation

HRID 2248742 reaction equation

[CH3:1][O:2][C:3]([CH2:5][S:6][CH:7](SCC(OC)=O)[CH:8]([CH3:13])[C:9](OC)=[O:10])=[O:4]>C[O-].[Na+].CO>[OH:10][C:9]1[C:8]([CH3:13])=[CH:7][S:6][C:5]=1[C:3]([O:2][CH3:1])=[O:4]

Participants

4

Reactant 1

HCID 19995022Methyl 3,3-bis(methoxycarbonyl methylthio)-2-methyl-propionate

Product 1

HCID 54710749Methyl 3-hydroxy-4-methylthiophene-2-carboxylate

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent

HCID 10942334Sodium MethoxideSolvent

Procedure

Dithioacetal of (b) above (0.08 mol) was dissolved in 120 ml of 2N sodium methoxide in methanol and stirred over night at room temperature.

Sources & evidence

ORD record: ord-910e94acaeac4f238276630e81ad0697
Source dataset: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05041461

Reaction notes

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