Potassium Hydroxide → Methyl 3-hydroxy-5-mercapto-4-methylthiphene-2-carboxylate

HRID 2248746Notes

Reaction equation

HRID 2248746 reaction equation
C(SC1SC=CC=1)(=O)C.C([S:13][C:14]1[S:18][C:17]([C:19]([O:21][CH3:22])=[O:20])=[C:16]([OH:23])[C:15]=1[CH3:24])(=O)C.[OH-].[K+]>CO>[OH:23][C:16]1[C:15]([CH3:24])=[C:14]([SH:13])[S:18][C:17]=1[C:19]([O:21][CH3:22])=[O:20]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 13133366Thiophene-2-thiol, S-acetyl-HCID 54710754Methyl 5-acetylthio-3-hydroxy-4-methylthiophene-2-carboxylate

Product 1

HCID 54684845Methyl 3-hydroxy-5-mercapto-4-methylthiphene-2-carboxylate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The acetylthiothiophene of (f) above (10 mmol) was added to 30 ml of 1M potassium hydroxide in methanol. After acidification of the mixture, the mercapto thiophene was obtained, recrystallising from hexane, m.p. 86°-88° C.

Sources & evidence

ORD record
ord-7076ab0dd12c417cb940f3f574dd7eb8
Source dataset
uspto-grants-1991_08
Patent number
US05041461

Reaction notes

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