反应详情

To a solution of 2-amino-6-chlorobenzonitrile (4.6 g) in chloroform (100 ml) is added triethylamine (4.8 ml), and thereto is added dropwise acetoxyacetyl chloride (3.8 ml). The mixture is stirred at room temperature for 1 hour, and thereafter, water is added thereto, and the mixture is extracted with chloroform. The organic layer is washed with saturated aqueous sodium chloride and then dried over anhydrous sodium sulfate, and the solvent is distilled off under reduced pressure. The resulting crude crystals are recrystallized from ethanol-water to give the title compound (3.8 g) having the following physical properties.

1. extractionthe mixture is extracted with chloroform
2. washThe organic layer is washed with saturated aqueous sodium chloride
3. dry with materialdried over anhydrous sodium sulfate
4. distillationthe solvent is distilled off under reduced pressure
5. customThe resulting crude crystals are recrystallized from ethanol-water