HRID2248789

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81410

2-Chlorobenzenesulfonamide

C6H6ClNO2S

结构：COc1cc(C(=O)O)ccc1Cc1c(Cl)n(C)c2ccc(CCNC(=O)N(C)C)cc12

HCID57243738

未命名化合物

PRODUCTS

生成物

结构：COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1c(Cl)n(C)c2ccc(CCNC(=O)N(C)C)cc12

HCID57174681

未命名化合物

PROCEDURE

实验过程

Using a similar procedure to that described in Example 2, part c, except starting from 4-[2-chloro-5-[2-(N',N'-dimethylureido)ethyl]-1-methylindol-3-ylmethyl]-3-methoxybenzoic acid, and using 2-chlorophenylsulfonamide instead of 2-methylphenylsulfonamide, the title compound was obtained (94%) as a white solid: mp 204°-206° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8b4b8fb9e324471cbdc1b600d7001bad
来源数据集: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05041460
来源说明: uspto-grants-1991_08

反应 SMILES

[Cl:1][C:2]1[N:3]([CH3:31])[C:4]2[C:9]([C:10]=1[CH2:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=O)=[CH:14][C:13]=1[O:21][CH3:22])=[CH:8][C:7]([CH2:23][CH2:24][NH:25][C:26]([N:28]([CH3:30])[CH3:29])=[O:27])=[CH:6][CH:5]=2.[Cl:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[S:39]([NH2:42])(=[O:41])=[O:40]>>[Cl:1][C:2]1[N:3]([CH3:31])[C:4]2[C:9]([C:10]=1[CH2:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:42][S:39]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=3[Cl:32])(=[O:41])=[O:40])=[O:18])=[CH:14][C:13]=1[O:21][CH3:22])=[CH:8][C:7]([CH2:23][CH2:24][NH:25][C:26]([N:28]([CH3:29])[CH3:30])=[O:27])=[CH:6][CH:5]=2