HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorobenzenesulfonamide → 4-[2-Chloro-5-[2-(N',N'-dimethylureido)ethyl]-1-methylindol-3-ylmethyl]-3-methoxy-N-(2-chlorophenylsulfonyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorobenzenesulfonamide | HCID 81410 | — |
| Reactant | 4-[2-chloro-5-[2-(N',N'-dimethylureido)ethyl]-1-methylindol-3-ylmethyl]-3-methoxybenzoic acid | HCID 57243738 | — |
| Product | 4-[2-Chloro-5-[2-(N',N'-dimethylureido)ethyl]-1-methylindol-3-ylmethyl]-3-methoxy-N-(2-chlorophenylsulfonyl)benzamide | HCID 57174681 | — |
Reaction Steps
Using a similar procedure to that described in Example 2, part c, except starting from 4-[2-chloro-5-[2-(N',N'-dimethylureido)ethyl]-1-methylindol-3-ylmethyl]-3-methoxybenzoic acid, and using 2-chlorophenylsulfonamide instead of 2-methylphenylsulfonamide, the title compound was obtained (94%) as a white solid: mp 204°-206° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05041460 |
| Source dataset | uspto-grants-1991_08 |
| ORD ID | ord-8b4b8fb9e324471cbdc1b600d7001bad |
| Source note | uspto-grants-1991_08 |