反应详情

A mixture of 8.72 parts of N4 -[(4-fluorophenyl)methyl]-4,5-pyrimidinediamine, 63 parts of carbon disulfide and 45 parts of N,N-dimethylformamide was stirred for 3 hours at reflux temperature. After cooling, the reaction mixture was poured into water. The precipitated product was filtered off and dried, yielding 10.1 parts (78.9%) of 9-[(4-fluorophenyl)methyl]-9H-purine-8-thiol (interm. 24).

1. temperatureat reflux temperature
2. temperatureAfter cooling
3. filtrationThe precipitated product was filtered off
4. customdried