Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | ethyl 4-[[6-chloro-7-[(4-fluorophenyl)methyl]-7H-purin-8-yl]amino]-1-piperidinecarboxylate | HCID 19785322 | — |
| Product | HCID 178419280 | HCID 178419280 | 100% |
Reaction Steps
A mixture of 7.5 parts of ethyl 4-[[6-chloro-7-[(4-fluorophenyl)methyl]-7H-purin-8yl]amino]-1-piperidinecarboxylate and 150 parts of a hydrobromic acid solution 48% in water was stirred overnight at 80° C. The reaction mixture was evaporated. The residue was stirred in 2-propanone. The product was filtered off and dried, yielding 8.5 parts (100%) of 7-[(4-fluorophenyl)methyl]-8-(4-piperidinylamino)-7H-purin-6-ol dihydrobromide as a residue (compound 41).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05041448 |
|---|
| Source dataset | uspto-grants-1991_08 |
|---|
| ORD ID | ord-0aba10100b094679b8a4252cfe7f64d2 |
|---|
| Source note | uspto-grants-1991_08 |
|---|
