Sodium Carbonate → HCID 10107780, compound

HRID 2248900Notes

Reaction equation

HRID 2248900 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7](/[CH:11]=[CH:12]/[C:13]2[CH:22]=[CH:21][C:20]3[C:15](=[CH:16][C:17]([Cl:23])=[CH:18][CH:19]=3)[N:14]=2)[CH:6]=1)(=O)C.C(=O)([O-])[O-].[Na+].[Na+]>CO>[Cl:23][C:17]1[CH:16]=[C:15]2[C:20]([CH:21]=[CH:22][C:13](/[CH:12]=[CH:11]/[C:7]3[CH:6]=[C:5]([OH:4])[CH:10]=[CH:9][CH:8]=3)=[N:14]2)=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 10245656HCID 10245656, compound

Product 1

HCID 10107780HCID 10107780, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of (E)-3-(7-chloro-2-quinolinylethenyl)phenyl acetate (7.4 g, 22.9 mmol) and anhydrous sodium carbonate (606 mg, 5.7 mmol) in 135 ml of methanol is stirred at room temperature for 36 hours. pH 7 buffer (250 ml) is added and the precipitated solid filtered and dried to afford (E)-3-(7-chloro-2-quinolinylethenyl)phenol which is used directly in the next step.

Workup

  1. additionpH 7 buffer (250 ml) is added
  2. filtrationthe precipitated solid filtered
  3. customdried

Sources & evidence

ORD record
ord-7d81ace1a2ee45769bfdc89fbcbb660e
Source dataset
uspto-grants-1991_08
Patent number
US05041453

Reaction notes

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