Hydrochloric Acid → HCID 14093656, compound

HRID 2248922Notes

Reaction equation

HRID 2248922 reaction equation
[Na].[C:2]([CH2:5][NH:6][C@@H:7]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C@@H:8]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[OH:9])([OH:4])=[O:3].Cl>O>[C:2]([CH2:5][NH:6][C@@H:7]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C@@H:8]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[OH:9])([OH:4])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86744320HCID 86744320, compound

Product 1

HCID 14093656HCID 14093656, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.50 g of (1R,2S)-2-carboxymethylamino-1,2-diphenylethanol mono sodium salt was dissolved in 60 ml of water and 1.2M hydrochloric acid was added to adjust the pH at 8. The precipitated crystals were washed 2 times with water and 2 times with methanol. The washed crystals were dried under reduced pressure (about 2 mm Hg) at 70° C. for 12 h. Yield 1.95 g (84%); mp 249°-251° C. (decomp.); [α]D21 +3.3 (c 1.00, 1M NaOH). IR (KBr): 3320, 3050, 2890, 1625, 1570, 1390, 760, 710, 700 cm-1 (the spectrum is identical with that of (1S,2R)-form).

Workup

  1. washThe precipitated crystals were washed 2 times with water and 2 times with methanol
  2. customThe washed crystals were dried under reduced pressure (about 2 mm Hg) at 70° C. for 12 h

Sources & evidence

ORD record
ord-c1a6d21de0de44af87dfd16405ec6c60
Source dataset
uspto-grants-1991_08
Patent number
US05041573

Reaction notes

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