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HRID2248944

反应详情

EQUATION

反应方程式

HRID 2248944 的结构方程式

REACTANTS

反应物

2
结构：ClB(Cl)Cl
HCID25135

Boron trichloride

BCl3

结构：Nc1nc2c(sc(=O)n2[C@@H]2O[C@H](COCc3ccccc3)[C@@H](OCc3ccccc3)[C@@H]2OCc2ccccc2)c(=O)[nH]1
HCID136197589

未命名化合物

PRODUCTS

生成物

1
结构：Nc1nc2c(sc(=O)n2[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)[nH]1
HCID136126104

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

CONDITIONS

反应条件

温度
-40 °C

PROCEDURE

实验过程

Compound 39 is dissolved in dry dichloromethane and deprotected using an excess of boron trichloride (1M in dichloromethane) at -78° C. and allowed to warm to -40° C. for 2 hours before quenching with methanol. The residue after workup is crystallized from water to yield 40 as a colorless crystalline solid.

WORKUP

后处理

  1. customat -78° C.
  2. custombefore quenching with methanol
  3. customThe residue after workup is crystallized from water