HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2248944Generated: October 31, 2026
Boron Trichloride → 5-amino-3-(beta-D-arabinofuranosyl)thiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione
https://huagongshe.com/reaction/2248944
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Boron Trichloride | HCID 25135 | — |
| Reactant | 5-Amino-3-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)thiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione | HCID 136197589 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-amino-3-(beta-D-arabinofuranosyl)thiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione | HCID 136126104 | — |
Reaction Steps
Compound 39 is dissolved in dry dichloromethane and deprotected using an excess of boron trichloride (1M in dichloromethane) at -78° C. and allowed to warm to -40° C. for 2 hours before quenching with methanol. The residue after workup is crystallized from water to yield 40 as a colorless crystalline solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05041426 |
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| Source dataset | uspto-grants-1991_08 |
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| ORD ID | ord-894e3069799a406f8476c8dfdde12415 |
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| Source note | uspto-grants-1991_08 |
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