反应详情

To a 10 ml of ice-cooled 1M solution of trimethylaluminum in hexane, was added dropwise a solution of 1.05 g of (+)-2,3,4,5,6-pentafluorostyrene oxide (over 95%ee) in 5 ml of hexane, to react for five hours at 0° C and for another one hour at room temperature. The similar work-up to Example 1 gave 1.10 g of (+)-2-(pentafluorophenyl)-1-propanol. The specific rotation was compared with that of Example 1, and the optical purity was determined to be 15%ee.

1. customto react for five hours at 0° C and for another one hour at room temperature