Methanol → 6-(Methoxycarbonylphenylthio)-6-tert.butyloxycarbonylhexanoic acid methyl ester

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Reaction Steps

1 g (30.2 mmol) of 2-(4-methoxycarbonylphenylthio)-2-tert. butoxycarbonylcyclohexanone is dissolved, together with 0.37 g (3.3 mmol) of potassium tert. butylate, in 100 ml of methanol of reagent purity and the solutions is left to stand for 2 hours at room temperature. It is then diluted with 500 ml of ethyl acetate and the organic phase is washed with water and a saturated sodium chloride solution, dried with sodium sulphate and concentrated by evaporation. After drying in a high vacuum 11.3 g of an oily product are obtained, which is sufficiently pure to be used for further reactions.

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