Hydrochloric Acid → HCID 131716989, compound

HRID 2249114Notes

Reaction equation

HRID 2249114 reaction equation
C(OC[C:5]([CH2:27]OCC)([OH:26])[CH:6]([NH:18]C(OC(C)(C)C)=O)[CH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1)C.[ClH:31]>>[ClH:31].[NH2:18][C@H:6]1[CH2:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][C:9]=2[C@H:27]([Cl:31])[C@@H:5]1[OH:26]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67865966HCID 67865966, compound

Product 1

HCID 131716989HCID 131716989, compound

Conditions

Temperature
100 °C

Procedure

A suspension of α, α-diethoxymethyl-β-tert-butoxycarbonylamino-1-naphthalenepropanol (250 mg), isomer A was stirred in 37% aqueous hydrochloric acid at 0° C. for 1 hour. The resulting emulsion was then stirred at 100° C. for 3 minutes and the flask was immediately cooled in an ice-water bath. The precipitate was filtered, washed with water and dried in vacuo to yield the title compound (152 mg) as a white solid.

Workup

  1. temperaturethe flask was immediately cooled in an ice-water bath
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-769d47e40cb1479e990917a52e8ec3e2
Source dataset
uspto-grants-1991_08
Patent number
US05041673

Reaction notes

Loading…