Hydrochloric Acid → HCID 131716990, compound

HRID 2249115Notes

Reaction equation

HRID 2249115 reaction equation
C(OC[C:5]([CH2:27]OCC)([OH:26])[CH:6]([NH:18]C(OC(C)(C)C)=O)[CH2:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1)C.[ClH:31]>>[ClH:31].[NH2:18][C@H:6]1[CH2:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][C:9]=2[C@H:27]([Cl:31])[C@H:5]1[OH:26]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 67865966HCID 67865966, compound

Product 1

HCID 131716990HCID 131716990, compound

Conditions

Temperature
100 °C

Procedure

A suspension of α, α-diethoxymethyl-β-tert-butoxycarbonylamino-1-naphthalenepropanol (252 mg), isomer B w as stirred in 37% aqueous hydrochloric acid at 0° C. for 50 minutes. The resulting suspension was then stirred at 100° C. for 3 minutes. The reaction flask was cooled at 0° C. and the precipitate was filtered, washed with water and dried in vacuo. The title compound (156 mg) was obtained as a white solid.

Workup

  1. temperatureThe reaction flask was cooled at 0° C.
  2. filtrationthe precipitate was filtered
  3. washwashed with water
  4. customdried in vacuo

Sources & evidence

ORD record
ord-b983717c313e402ba984e0b2722f17c1
Source dataset
uspto-grants-1991_08
Patent number
US05041673

Reaction notes

Loading…