HCID 19995563, compound → HCID 19995551, compound

HRID 2249120Notes

Reaction equation

HRID 2249120 reaction equation
[CH2:1]([O:3][CH2:4][C:5]([CH2:22][O:23][CH2:24][CH3:25])([OH:21])[CH:6]([N+:18]([O-])=O)[CH2:7][C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[C:10]([O:16][CH3:17])[CH:9]=1)[CH3:2]>[Ni]>[CH2:24]([O:23][CH2:22][C:5]([CH2:4][O:3][CH2:1][CH3:2])([OH:21])[CH:6]([NH2:18])[CH2:7][C:8]1[CH:9]=[C:10]([O:16][CH3:17])[CH:11]=[C:12]([O:14][CH3:15])[CH:13]=1)[CH3:25]

Participants

3

Reactant 1

HCID 19995563HCID 19995563, compound

Product 1

HCID 19995551HCID 19995551, compoundYield 76.6%

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

α,α-Diethoxymethyl-β-nitro-3,5-dimethoxybenzenepropanol (3.39 g) was hydrogenated in isoproipanol (50 ml) over Raney nickel at atmospheric pressure and room temperature. When hydrogen absorption was complete, the reaction mixture was degased for 15 minutes under vacuum and the catalyst was filtered on celite. The solvent was evaporated under vacuum to yield the title compound as an oil (2.38 g).

Workup

  1. customWhen hydrogen absorption
  2. customthe reaction mixture was degased for 15 minutes under vacuum
  3. filtrationthe catalyst was filtered on celite
  4. customThe solvent was evaporated under vacuum

Sources & evidence

ORD record
ord-49f4683af2964ff290a7c8f0e50d8eaf
Source dataset
uspto-grants-1991_08
Patent number
US05041673

Reaction notes

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