反应详情

A mixture of 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman (6.1 g), anhydrous dimethylamine (15 ml) and ethanol were left to stand at ambient temperature until tlc showed that reaction was complete (c. 2 hrs.). Removal of the solvent in vacuo gave 7-(2-hydroxy-3-dimethylaminopropoxy)-2,2-dimethyl-4-phenylchroman (6.8 g, 97%) isolated as the hydrochloride salt, m.p. 210°-215°, from acetone-ethanol.

1. waitwere left
2. customto stand at ambient temperature until tlc
3. customshowed that reaction
4. custom(c. 2 hrs.)
5. customRemoval of the solvent in vacuo