HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 7-(2-Hydroxy-3-dimethylaminopropoxy)-2,2-dimethyl-4-phenylchroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 7-(2,3-Epoxypropoxy)-2,2-dimethyl-4-phenylchroman | HCID 23330756 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-(2-Hydroxy-3-dimethylaminopropoxy)-2,2-dimethyl-4-phenylchroman | HCID 3046428 | 97% |
Reaction Steps
A mixture of 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-phenylchroman (6.1 g), anhydrous dimethylamine (15 ml) and ethanol were left to stand at ambient temperature until tlc showed that reaction was complete (c. 2 hrs.). Removal of the solvent in vacuo gave 7-(2-hydroxy-3-dimethylaminopropoxy)-2,2-dimethyl-4-phenylchroman (6.8 g, 97%) isolated as the hydrochloride salt, m.p. 210°-215°, from acetone-ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04234726 |
| Source dataset | uspto-grants-1980_11 |
| ORD ID | ord-58405ad77fc347029602cc3d79db48fd |
| Source note | uspto-grants-1980_11 |