Methylamine → HCID 23330759, compound

HRID 224930Notes

Reaction equation

HRID 224930 reaction equation
[CH3:1][NH2:2].[O:3]1[CH2:29][CH:4]1[CH2:5][O:6][C:7]1[CH:16]=[C:15]2[C:10]([CH:11]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][CH:20]=3)[CH2:12][C:13]([CH3:18])([CH3:17])[O:14]2)=[CH:9][CH:8]=1>C(O)C>[C:19]1([CH:11]2[C:10]3[C:15](=[CH:16][C:7]([O:6][CH2:5][CH:4]([OH:3])[CH2:29][NH:2][CH3:1])=[CH:8][CH:9]=3)[O:14][C:13]([CH3:18])([CH3:17])[CH2:12]2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 23330745HCID 23330745, compound

Product 1

HCID 23330759HCID 23330759, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methylamine (7 ml) was added to 7-(2,3-epoxypropoxy)-2,2-dimethyl-4-(1-naphthyl)chroman (3.3 g., 0.0092 moles) in ethanol (7 ml) and the solution left to stand at room temperature for 48 hours. Removal of solvent gave the title compound as a dark coloured oil which was converted to the hydrochloride salt. Recrystallization from 1:1 petroleum ether:ether gave a grey solid (0.85 g., 24%) m.p. 96°-100° C.

Workup

  1. waitthe solution left
  2. customRemoval of solvent

Sources & evidence

ORD record
ord-f9f28d7c4673421cb82540de2d735d2a
Source dataset
uspto-grants-1980_11
Patent number
US04234726

Reaction notes

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