Hydrochloric Acid → HCID 86613846, compound

HRID 2249399Notes

Reaction equation

HRID 2249399 reaction equation
C([NH:4][C:5]1[CH:10]=[C:9]([C:11]2[C:16]([F:17])=[CH:15][C:14]([C:18]#[N:19])=[C:13]([O:20][CH3:21])[C:12]=2[F:22])[N:8]=[CH:7][C:6]=1[Cl:23])(=O)C.[OH-:24].[Na+].Cl.[CH3:27][OH:28]>O>[NH2:4][C:5]1[CH:10]=[C:9]([C:11]2[C:16]([F:17])=[CH:15][C:14]([C:18]#[N:19])=[C:13]([O:20][CH3:21])[C:12]=2[F:22])[N:8]=[C:7]([C:27]([OH:28])=[O:24])[C:6]=1[Cl:23]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 86613847HCID 86613847, compound

Product 1

HCID 86613846HCID 86613846, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A slurry of 4-acetylamino-3-chloro-6-(4-cyano-2,6-difluoro-3-methoxyphenyl)pyridine (0.13 g, 0.33 mmol) in methanol (5 mL) was treated with 1N sodium hydroxide (1.7 mL) and stirred at ambient temperature for 1 hour. The solution was diluted with water (15 mL) and acidified with 1N hydrochloric acid (1.7 mL) and the solid collected (0.095 g). Analysis by 1H NMR showed the 4-amino-3-chloro-6-(4-cyano-2,6-difluoro-3-methoxyphenyl)pyridine-2-carboxylic acid and an impurity. This material was used without further purification.

Workup

  1. customthe solid collected (0.095 g)
  2. customThis material was used without further purification

Sources & evidence

ORD record
ord-4de4b573d39e4c1198284ffe36b7fd9b
Source dataset
uspto-grants-2008_01
Patent number
US07314849B2

Reaction notes

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