4-Fluorobenzyl chloride → 4-carboxy-2-(4-fluorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one

HRID 2249413Notes

Reaction equation

HRID 2249413 reaction equation
[C:1]([C:4]1[C:5](=[O:23])[N:6]([CH2:19][CH:20]2[CH2:22][CH2:21]2)[N:7]=[C:8]([C:10]2[CH:11]=[CH:12][C:13]3[O:17][CH2:16][CH2:15][C:14]=3[CH:18]=2)[CH:9]=1)([OH:3])=[O:2].O1C2C=CC(C3C=C(C(OC)=O)C(=O)NN=3)=CC=2CC1.[F:44][C:45]1C=CC(CCl)=[CH:47][CH:46]=1>>[C:1]([C:4]1[C:5](=[O:23])[N:6]([CH2:19][C:20]2[CH:47]=[CH:46][C:45]([F:44])=[CH:21][CH:22]=2)[N:7]=[C:8]([C:10]2[CH:11]=[CH:12][C:13]3[O:17][CH2:16][CH2:15][C:14]=3[CH:18]=2)[CH:9]=1)([OH:3])=[O:2]

Participants

4

Reactant 3

HCID 96024-Fluorobenzyl chlorideHCID 23094117HCID 23094117, compoundHCID 230941314-carboxy-2-cyclopropylmethyl-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one

Product 1

HCID 230941364-carboxy-2-(4-fluorobenzyl)-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-oneYield 54.7%

Procedure

The general procedure of Example 1 (3) was carried out by use of 6-(2,3-dihydro-1-benzofuran-5-yl)-4-methoxycarbonyl-2H-pyridazin-3-one and 4-fluorobenzyl chloride, to thereby yield the title compound as a yellow powder (yield: 54.7%).

Sources & evidence

ORD record
ord-c9f4a0cdde8642fabb41bbb45a98fb79
Source dataset
uspto-grants-2008_01
Patent number
US07314877B2

Reaction notes

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