4-Fluorobenzyl chloride → 6-(1-benzofuran-5-yl)-4-carboxy-2-(4-fluorobenzyl)-2H-pyridazin-3-one

HRID 2249427Notes

Reaction equation

HRID 2249427 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:11]=[C:12]([C:17]([O:19]C)=[O:18])[C:13](=[O:16])[NH:14][N:15]=3)=[CH:9][C:4]=2[CH:3]=[CH:2]1.[F:21][C:22]1[CH:29]=[CH:28][C:25]([CH2:26]Cl)=[CH:24][CH:23]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10]3[CH:11]=[C:12]([C:17]([OH:19])=[O:18])[C:13](=[O:16])[N:14]([CH2:26][C:25]4[CH:28]=[CH:29][C:22]([F:21])=[CH:23][CH:24]=4)[N:15]=3)=[CH:9][C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 96024-Fluorobenzyl chlorideHCID 23094139HCID 23094139, compound2×

Product 1

HCID 230941196-(1-benzofuran-5-yl)-4-carboxy-2-(4-fluorobenzyl)-2H-pyridazin-3-oneYield 73.4%

Procedure

The general procedure of Example 1 (3) was carried out by use of 6-(1-benzofuran-5-yl)-4-methoxycarbonyl-2H-pyridazin-3-one and 4-fluorobenzyl chloride, to thereby yield the title compound as a yellow powder (yield: 73.4%).

Sources & evidence

ORD record
ord-a527ecfac42c418dbce566259ad00352
Source dataset
uspto-grants-2008_01
Patent number
US07314877B2

Reaction notes

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