3-(4-Chlorophenyl)propyl methanesulfonate → 4-carboxy-2-[3-(4-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-one

HRID 2249430Notes

Reaction equation

HRID 2249430 reaction equation
ClC1C=CC=CC=1CCCN1C(=O)C(COS(C)(=O)=O)=CC(C2C=CC3OCCC=3C=2)=N1.[O:33]1[C:37]2[CH:38]=[CH:39][C:40]([C:42]3[CH:43]=[C:44]([C:49]([O:51]C)=[O:50])[C:45](=[O:48])[NH:46][N:47]=3)=[CH:41][C:36]=2[CH2:35][CH2:34]1.CS(O[CH2:58][CH2:59][CH2:60][C:61]1[CH:66]=[CH:65][C:64]([Cl:67])=[CH:63][CH:62]=1)(=O)=O>>[C:49]([C:44]1[C:45](=[O:48])[N:46]([CH2:58][CH2:59][CH2:60][C:61]2[CH:66]=[CH:65][C:64]([Cl:67])=[CH:63][CH:62]=2)[N:47]=[C:42]([C:40]2[CH:39]=[CH:38][C:37]3[O:33][CH2:34][CH2:35][C:36]=3[CH:41]=2)[CH:43]=1)([OH:51])=[O:50]

Participants

4

Reactant 3

HCID 130797053-(4-Chlorophenyl)propyl methanesulfonateHCID 23094117HCID 23094117, compoundHCID 230941182-[3-(2-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 230941344-carboxy-2-[3-(4-chlorophenyl)propyl]-6-(2,3-dihydro-1-benzofuran-5-yl)-2H-pyridazin-3-oneYield 71%

Procedure

The general procedure of Example 1 (3) was carried out by use of 6-(2,3-dihydro-1-benzofuran-5-yl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3-(4-chlorophenyl)-1-propanol methanesulfonate, to thereby yield the title compound as a yellow powder (yield: 71.0%).

Sources & evidence

ORD record
ord-14dea6e2d62f4aa683f9f9746ed6a4c8
Source dataset
uspto-grants-2008_01
Patent number
US07314877B2

Reaction notes

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