Hydrochloric Acid → 224789-15-5

HRID 2249461Notes

Reaction equation

HRID 2249461 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH3:20])[CH2:15][CH2:14]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:21]1[NH:26][C:25](=[O:27])[C:24]2=[C:28]([CH3:34])[N:29]=[C:30]([CH2:31][CH2:32][CH3:33])[N:23]2[N:22]=1)[CH3:2].[Cl:35]CCl.[ClH:38]>CCOCC>[ClH:35].[ClH:38].[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:13]2[CH2:14][CH2:15][N:16]([CH2:19][CH3:20])[CH2:17][CH2:18]2)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:21]1[NH:26][C:25](=[O:27])[C:24]2=[C:28]([CH3:34])[N:29]=[C:30]([CH2:31][CH2:32][CH3:33])[N:23]2[N:22]=1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 135400189Vardenafil

Product 1

HCID 135414253224789-15-5

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

0.35 g (0.712 mmol) of 2-[2-ethoxy-5-(4-ethyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazine-4-one are suspended in 8 ml of ether and dichloromethane is added until a homogeneous solution is formed. 24 ml of a 1M solution of HCl in ether are added and the mixture is stirred at room temperature for 20 minutes and filtered off with suction. This gives 372 mg (99%) of 2-[2-ethoxy-5-(4-ethyl-piperazine-1-sulphonyl)-phenyl]-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazine-4-one dihydrochloride.

Workup

  1. customis formed
  2. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-69ad5230fb554c65875ea8fd8d6a1acd
Source dataset
uspto-grants-2008_01
Patent number
US07314871B2

Reaction notes

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