Pyrrolidine → HCID 59639692, compound

HRID 2249522Notes

Reaction equation

HRID 2249522 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[I:6][C:7]1[CH:8]=[C:9]([C:12](=[O:17])C(Cl)(Cl)Cl)[NH:10][CH:11]=1>C(#N)C>[I:6][C:7]1[CH:8]=[C:9]([C:12]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:17])[NH:10][CH:11]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 116816022,2,2-trichloro-1-(4-iodo-1H-pyrrol-2-yl)ethan-1-one

Product 1

HCID 59639692HCID 59639692, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Pyrrolidine (3 mL, 35.62 mmol) was added to a stirred solution of 4-iodo-2(trichloroacetyl)pyrrole (10 g, 29.69 mmol) in acetonitrile (50 mL) at room temperature. The mixture was stirred at room temperature for 1 hr. The white precipitate was filtered and washed with acetonitrile (25 mL) to give title compound as a white solid (7.3 g, 86%).; Mass Spec FIA MS 291.

Workup

  1. filtrationThe white precipitate was filtered
  2. washwashed with acetonitrile (25 mL)

Sources & evidence

ORD record
ord-9b94874cefd64ea8b27b78615872080f
Source dataset
uspto-grants-2008_01
Patent number
US07314885B2

Reaction notes

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