Methanol → 70288-74-3

HRID 224956Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:7])[CH:4](Br)[CH3:5].[O-:8][C:9]#[N:10].[K+].[CH3:12][OH:13]>>[CH3:1][O:2][C:3](=[O:7])[CH:4]([NH:10][C:9]([O:13][CH3:12])=[O:8])[CH3:5]

Participants

Reactant 3

HCID 887Methanol

HCID 95576Methyl 2-bromopropionate

HCID 11378442Potassium cyanate

Product 1

HCID 642186470288-74-3Yield 59%

Procedure

From the reaction of 11.69 grams of 2-bromopropionic acid methyl ester with 8.52 grams of potassium cyanate and 7.85 grams of methanol under the conditions described in Example 1 there were isolated 6.66 grams (59%) of 2-methoxycarbonylaminopropionic acid methyl ester with a boiling point of 65°-67° C./0.0013 mbar.

Sources & evidence

ORD record: ord-17b1c62716884293a7f30fb49e02d387
Source dataset: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04234744

Reaction notes

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