Methanol → 2-Methoxycarbonylamino-4-methyl valeric acid methyl ester

HRID 224957Notes

Reaction equation

HRID 224957 reaction equation
[CH3:1][O:2][C:3](=[O:10])[CH:4](Br)[CH2:5][CH:6]([CH3:8])[CH3:7].[O-:11][C:12]#[N:13].[K+].[CH3:15][OH:16]>>[CH3:1][O:2][C:3](=[O:10])[CH:4]([NH:13][C:12]([O:16][CH3:15])=[O:11])[CH2:5][CH:6]([CH3:8])[CH3:7]

Participants

4

Reactant 3

HCID 887Methanol2×HCID 11378442Potassium cyanate2×HCID 12957039Methyl 2-bromo-4-methylpentanoate

Product 1

HCID 140365862-Methoxycarbonylamino-4-methyl valeric acid methyl esterYield 66%

Procedure

14.64 grams of 2-bromo-4-methyl valeric acid methyl ester were brought to reaction with potassium cyanate and methanol in the manner described in Example 1 (using the same amounts of potassium cyanate and methanol as in Example 1 ), reaction time 1 hour and then worked up. There were obtained 9.39 grams (66%) of 2-methoxycarbonylamino-4-methyl valeric acid methyl ester with a boiling point of 100° C./0.0013 mbar.

Workup

  1. customreaction time 1 hour

Sources & evidence

ORD record
ord-f37da4faf31f4a6f901ba290ca6bfca5
Source dataset
uspto-grants-1980_11
Patent number
US04234744

Reaction notes

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