反应详情

In 6 ml of methanol is dissolved 0.57 g of methyl 2-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]acetate. After adding 0.72 ml of 5 mol/L solution of sodium hydroxide, the mixture thus obtained is stirred at ambient temperature for one hour and thereafter at 50-60° C. for one hour. Chloroform and water are added to the reaction mixture, pH is adjusted to 2.0 with 2 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is successively washed with water and saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. Thus, 0.45 g of 2-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]acetic acid is obtained as a colorless crystalline product.

1. customthe mixture thus obtained
2. waitat 50-60° C. for one hour
3. customthe organic layer is separated
4. washThe organic layer is successively washed with water and saturated aqueous solution of sodium chloride
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationthe solvent is distilled off under reduced pressure