Sodium Hydroxide → HCID 68983776, compound

HRID 2249619Notes

Reaction equation

HRID 2249619 reaction equation
[CH2:1]([O:5][C:6]1[CH:29]=[C:28]([O:30][CH2:31][CH:32]([CH3:34])[CH3:33])[CH:27]=[CH:26][C:7]=1[C:8]([C:10]1[CH:11]=[CH:12][C:13]([O:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[C:14]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH:15]=1)=[O:9])[CH:2]([CH3:4])[CH3:3].[OH-].[Na+:36]>C(O)C>[CH2:1]([O:5][C:6]1[CH:29]=[C:28]([O:30][CH2:31][CH:32]([CH3:34])[CH3:33])[CH:27]=[CH:26][C:7]=1[C:8]([C:10]1[CH:11]=[CH:12][C:13]([O:21][CH2:22][CH:23]([CH3:25])[CH3:24])=[C:14]([CH2:16][CH2:17][C:18]([O-:20])=[O:19])[CH:15]=1)=[O:9])[CH:2]([CH3:4])[CH3:3].[Na+:36]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57684398HCID 57684398, compound

Product 1

HCID 68983776HCID 68983776, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 90 ml of ethanol is dissolved 9.0 g of 3-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]-propionic acid. After adding 18.2 ml of 1 mol/L aqueous solution of sodium hydroxide, the mixture is stirred at ambient temperature for 10 minutes. The solvent is distilled off from the reaction mixture under reduced pressure, and the residue is purified by reverse phase silica gel column chromatography [eluent; acetonitrile:water=1:1] to obtain 7.6 g of sodium 3-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]-propionate as a colorless foaming product.

Workup

  1. distillationThe solvent is distilled off from the reaction mixture under reduced pressure
  2. customthe residue is purified by reverse phase silica gel column chromatography [eluent; acetonitrile:water=1:1]

Sources & evidence

ORD record
ord-f885e12ce661415b9d62373778657bb3
Source dataset
uspto-grants-2008_01
Patent number
US07314888B1

Reaction notes

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