Sodium Hydroxide → HCID 68983776, compound

Participants

Reaction Steps

In 90 ml of ethanol is dissolved 9.0 g of 3-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]-propionic acid. After adding 18.2 ml of 1 mol/L aqueous solution of sodium hydroxide, the mixture is stirred at ambient temperature for 10 minutes. The solvent is distilled off from the reaction mixture under reduced pressure, and the residue is purified by reverse phase silica gel column chromatography [eluent; acetonitrile:water=1:1] to obtain 7.6 g of sodium 3-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]-propionate as a colorless foaming product.

Provenance & Evidence