反应详情

In 15 ml of methylene chloride is dissolved 1.50 g of methyl 2-[5-(2,4-diisobutoxybenzoyl)-2-isobutoxyphenyl]acetate, to which is added 1.06 g of aluminum chloride at ambient temperature. The mixture is stirred at ambient temperature for 2 hours. The reaction mixture is added to a mixture of chloroform and ice water, and the organic layer is separated. The organic layer thus obtained is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. The residue thus obtained is purified by silica gel column chromatography (eluent; hexane:ethyl acetate=5:1) to obtain 0.62 g of methyl 2-[5-(2-hydroxy-4-isobutoxybenzoyl)-2-isobutoxyphenyl]acetate as a yellow-colored solid product.

1. customthe organic layer is separated
2. customThe organic layer thus obtained
3. washis washed with water and saturated aqueous solution of sodium chloride successively
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationthe solvent is distilled off under reduced pressure
6. customThe residue thus obtained
7. customis purified by silica gel column chromatography (eluent; hexane:ethyl acetate=5:1)