反应详情

In 2 ml of methanol is dissolved 0.13 g of methyl 2-[5-(4-isobutoxy-2-isopentyloxybenzoyl)-2-isobutoxyphenyl]acetate, to which is added 0.2 ml of 5 mol/L solution of sodium hydroxide. The mixture thus obtained is stirred at ambient temperature for one hour and then at 50-60° C. for one hour. Chloroform and water are added to the reaction mixture, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and the solvent is distilled off under reduced pressure. The residue thus obtained is purified by silica gel column chromatography (eluent; hexane:ethyl acetate=2:1) to obtain 0.07 g of 2-[5-(4-isobutoxy-2-isopentyloxybenzoyl)-2-isobutoxyphenyl]acetic acid as a white-colored solid product.

1. customThe mixture thus obtained
2. waitat 50-60° C. for one hour
3. customthe organic layer is separated
4. washThe organic layer is washed with water and saturated aqueous solution of sodium chloride successively
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationthe solvent is distilled off under reduced pressure
7. customThe residue thus obtained
8. customis purified by silica gel column chromatography (eluent; hexane:ethyl acetate=2:1)