反应详情

温度

50 °C

In 13 ml of methanol is dissolved 2.5 g of isobutyl 3,5-diisobutoxybenzoate, to which is then added 2.3 ml of 5 mol/L sodium hydroxide solution. The mixture thus obtained is stirred at 50° C. for 3 hours. Chloroform and water are added to the reaction mixture, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and then the solvent is distilled off under reduced pressure. Thus, 1.8 g of 3,5-diisobutoxybenzoic acid is obtained as a white solid product.

1. customThe mixture thus obtained
2. customthe organic layer is separated
3. washThe organic layer is washed with water and saturated aqueous solution of sodium chloride successively
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationthe solvent is distilled off under reduced pressure