反应详情

In 38 ml of acetonitrile is dissolved 4.1 g of 5-formyl-2-isobutoxyphenyl acetate. To the solution thus obtained, 6.8 g of sodium dihydrogenphosphate dissolved in 20 ml of water and 3.6 ml of 30% aqueous hydrogen peroxide are successively added at ambient temperature, and then 3.6 g of sodium chlorite dissolved in 18 ml of water is dropwise added at 5-10° C. The mixture thus obtained is stirred at ambient temperature for 2 hours. Chloroform and water are added to the reaction mixture, the organic layer is separated, the organic layer thus obtained is washed successively with 5% aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate, and then the solvent is distilled off under reduced pressure. Thus, 4.0 g of 3-(acetyloxy)-4-isobutoxybenzoic acid is obtained as a light yellow solid product.

1. customTo the solution thus obtained
2. additionis dropwise added at 5-10° C
3. customThe mixture thus obtained
4. customthe organic layer is separated
5. customthe organic layer thus obtained
6. washis washed successively with 5% aqueous solution of sodium thiosulfate and saturated aqueous solution of sodium chloride
7. dry with materialdried over anhydrous magnesium sulfate
8. distillationthe solvent is distilled off under reduced pressure