HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (7R,8R,9R)-2,3-dimethyl-7,8-dihydroxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (7R,8R,9R)-10-Acetyl-7,8-dihydroxy-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h]-[1,7]naphthyridine | HCID 69288589 | — |
| Solvent | Ethanolamine | HCID 700 | — |
| Product | (7R,8R,9R)-2,3-dimethyl-7,8-dihydroxy-9-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine | HCID 10215014 | — |
Reaction Steps
The N-acetyl protecting group is detached from the compound (7R,8R,9R)-10-acetyl-7,8-dihydroxy-2,3-dimethyl-9-phenyl-7,8,9,10-tetrahydroimidazo[1,2-h][1,7]naphthyridine by heating with potassium carbonate in 2-aminoethanol (temp. 70-100° C.). After extractive workup and crystallization, the title compound is obtained as a colourless solid of m.p. 206-209° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07314935B2 |
| Source dataset | uspto-grants-2008_01 |
| ORD ID | ord-1bc5c881d2644bb6bae96cf60a35671f |
| Source note | uspto-grants-2008_01 |