Methylamine → HCID 178485103, compound

HRID 224973Notes

Reaction equation

HRID 224973 reaction equation
[CH3:1][N:2]=[C:3]([NH2:21])[NH:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15](=[N:18][C:19]#[N:20])SC)[N:9]=1.[CH3:22][NH2:23]>C(O)C>[CH3:1][N:2]=[C:3]([NH2:21])[NH:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:15]([NH:23][CH3:22])=[N:18][C:19]#[N:20])[N:9]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178485104HCID 178485104, compound

Product 1

HCID 178485103HCID 178485103, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-(2-methylguanidino)-4-[4-(3-cyano-2-methylisothioureido)butyl]thiazole (0.38 g.) in ethanol (10 ml.) was added 33% w/v ethanolic methylamine (40 ml.). The mixture was stirred overnight, evaporated to dryness and the residue triturated with water. The solid thus obtained was filtered and dried to give 2-(2-methylguanidino)-4-[4-(2-cyano-3-methylguanidino)butyl]thiazole, m.p. 119°-122° C.

Workup

  1. customevaporated to dryness
  2. customthe residue triturated with water
  3. customThe solid thus obtained
  4. filtrationwas filtered
  5. customdried

Sources & evidence

ORD record
ord-eb06f3f186144df48a40c2e600194adb
Source dataset
uspto-grants-1980_11
Patent number
US04234735

Reaction notes

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