反应详情

To a solution of 2-guanidino-4-(4-aminobutyl)thiazole (0.8 g.) in ethanol (10 ml.) was added dimethyl (cyanoimido)dithiocarbonate (0.6 g.). The mixture was stirred overnight. The white precipitate was filtered off and recrystallized from acetonitrile to give 2-guanidino-4-[4-(3-cyano-2-methylisothioureido)butyl]thiazole, m.p. 178°-180° C.

1. filtrationThe white precipitate was filtered off
2. customrecrystallized from acetonitrile