HCID 178512644, compound → HCID 178503912, compound

HRID 224974Notes

Reaction equation

HRID 224974 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[N:9]=1)[C:2]([NH2:4])=[NH:3]>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH:14][C:5](=[N:1][C:2]#[N:3])[S:6][CH3:7])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Participants

3

Reactant 1

HCID 178512644HCID 178512644, compound

Product 1

HCID 178503912HCID 178503912, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-guanidino-4-(4-aminobutyl)thiazole (0.8 g.) in ethanol (10 ml.) was added dimethyl (cyanoimido)dithiocarbonate (0.6 g.). The mixture was stirred overnight. The white precipitate was filtered off and recrystallized from acetonitrile to give 2-guanidino-4-[4-(3-cyano-2-methylisothioureido)butyl]thiazole, m.p. 178°-180° C.

Workup

  1. filtrationThe white precipitate was filtered off
  2. customrecrystallized from acetonitrile

Sources & evidence

ORD record
ord-f97b27b968ba4074b7d0e85b6e9c03c4
Source dataset
uspto-grants-1980_11
Patent number
US04234735

Reaction notes

Loading…