反应详情

To a solution of 2-guanidino-4-(4-phthalimidobutyl)imidazole (0.25 g.) in water/ethanol 1:1 v/v (20 ml.) was added sufficient dilute sodium hydroxide solution to give a pH of 12. The mixture was heated under reflux for 30 minutes, the pH adjusted to 3 with concentrated hydrochloric acid, the mixture heated under reflux a further 30 minutes and then cooled. The pH was readjusted to 12 with sodium hydroxide solution and then the total mixture evaporated to dryness to give crude 2-guanidino-4-(4-aminobutyl)imidazole which was used without further purification.

1. customto give a pH of 12
2. temperatureThe mixture was heated
3. temperatureunder reflux for 30 minutes
4. temperaturethe mixture heated
5. temperatureunder reflux a further 30 minutes
6. temperaturecooled
7. customthe total mixture evaporated to dryness