反应详情

A mixture of phthalic anhydride (5.3 g.) and 7-amino-heptanoic acid (5.8 g.) was heated at 185°-190° C. for 40 minutes and then cooled. The cooled partially solidified product was dissolved in ethyl acetate and the solution washed several times with dilute HCl. The organic layer was dried (MgSO4), filtered and evaporated to dryness and the residue recrystallized from acetic acid to give 7-phthalimidoheptanoic acid (5 g.), m.p. 112°-115° C.

1. temperaturewas heated at 185°-190° C. for 40 minutes
2. temperaturecooled
3. temperatureThe cooled partially solidified product
4. washthe solution washed several times with dilute HCl
5. dry with materialThe organic layer was dried (MgSO4)
6. filtrationfiltered
7. customevaporated to dryness
8. customthe residue recrystallized from acetic acid