2-Amino-2-methyl-1,3-propanediol → HCID 59639573, compound

HRID 2249834Notes

Reaction equation

HRID 2249834 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12](S(C)(=O)=O)[N:13]=2)=[C:4]([CH3:30])[CH:3]=1.[NH2:31][C:32]([CH3:37])([CH2:35][OH:36])[CH2:33][OH:34]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]3[CH:21]=[CH:20][C:19](=[O:22])[N:18]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=4[CH3:29])[C:10]=3[N:11]=[C:12]([NH:31][C:32]([CH2:35][OH:36])([CH3:37])[CH2:33][OH:34])[N:13]=2)=[C:4]([CH3:30])[CH:3]=1

Participants

3

Reactant 2

HCID 15312-Amino-2-methyl-1,3-propanediolHCID 59639608HCID 59639608, compound

Product 1

HCID 59639573HCID 59639573, compoundYield 62%

Procedure

Following the general procedure outlined in Example 60, the product of Example 121 (200 mg, 0.47 mmol) and 2-amino-2-methyl-1,3-propanediol (494 mg, 4.7 mmol) were reacted to give the crude material, which was purified as described in Example 126 to give the desired product 130 mg (62%). LC-MS: 449.0 (MH+, m/z), 1.67 (Rt, min).

Workup

  1. customto give the crude material, which
  2. customwas purified

Sources & evidence

ORD record
ord-46ec2055d2d04f70ad1c46ff4bdc8f79
Source dataset
uspto-grants-2008_01
Patent number
US07314881B2

Reaction notes

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