Dimethylamine → HCID 59639578, compound

HRID 2249835Notes

Reaction equation

[CH3:1][NH:2][CH3:3].C[Al](C)C.[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[N:16]1[C:21]2[N:22]=[C:23]([NH:34][CH2:35][C:36]([O:38]C)=O)[N:24]=[C:25]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[CH3:33])[C:20]=2[CH:19]=[CH:18][C:17]1=[O:40]>>[F:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([F:8])[C:10]=1[N:16]1[C:21]2[N:22]=[C:23]([NH:34][CH2:35][C:36]([N:2]([CH3:3])[CH3:1])=[O:38])[N:24]=[C:25]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[CH3:33])[C:20]=2[CH:19]=[CH:18][C:17]1=[O:40]

Participants

Reactant 3

HCID 674Dimethylamine

HCID 16682925Trimethylaluminum

HCID 59639612HCID 59639612, compound

Product 1

HCID 59639578HCID 59639578, compoundYield 54.5%

Procedure

Following the general procedure outlined in Example 193, dimethylamine (1.1 mL, 2.2 mmol), trimethylaluminum (1.1 mL, 2.2 mmol) and the product of Example 190 (100 mg, 0.22 mmol) were reacted to give the desired product 56 mg (54%). LC-MS: 468.2 (MH+, m/z), 2.00 (Rt, min).

Sources & evidence

ORD record: ord-54fe39b74d0240edb688b73feba01f15
Source dataset: uspto-grants-2008_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07314881B2

Reaction notes

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