Creatine → Potassium 2-(1-methylguanidino)acetate

HRID 2249920Notes

Reaction equation

HRID 2249920 reaction equation
[O:1]=[C:2]([CH2:4][N:5]([C:7](=[NH:9])[NH2:8])[CH3:6])[OH:3].[OH-].[K+:11]>O>[CH3:6][N:5]([CH2:4][C:2]([O-:3])=[O:1])[C:7]([NH2:9])=[NH:8].[K+:11]

Participants

4

Reactant 2

HCID 586CreatineHCID 14797Potassium Hydroxide

Product 1

HCID 59641369Potassium 2-(1-methylguanidino)acetate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Separately, in a single-necked, round bottomed flask, equipped with a magnetic stirrer, 7.87 g (60 mmol) of creatine is dissolved in 600 ml of water. To this is added 72 ml of 1M potassium hydroxide with vigorous stirring, until heat production ceases. At this point the water is removed by evaporation to yield the carboxylate salt, potassium 2-(1-methylguanidino)acetate, shown below.

Workup

  1. customSeparately, in a single-necked, round bottomed flask, equipped with a magnetic stirrer
  2. temperatureuntil heat production ceases
  3. customAt this point the water is removed by evaporation

Sources & evidence

ORD record
ord-0f8f3bc8a0db4764890beae53452da8d
Source dataset
uspto-grants-2008_01
Patent number
US07314945B1

Reaction notes

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